Pro tip: Try to reach level 40 in pickpocketing and learn the Poisoned perk. Swing with confidence, but aim your strikes! Use them wisely and wield your poisoned weapons carefully – the effects don’t last forever and your allies are vulnerable to them too. In any case, most of these poisons prove to be quite effective in many scenarios. For example, a poison that causes enemies to become vulnerable to fire might be better used by a battlemage skilled in flame destruction spells. I do recommend using certain types of poisons for specific situations, though. Now I’ve created a list here of the 10 best poisons that you can find and purchase in Skyrim, so you can decide which of these to get in order to make your weapons deadlier.
Please, refrain from drinking any of these poisons. These effects tend to be extremely negative (for your enemies) and are aimed at causing a lot of damage to foes. Poisons are items that can be applied to weapons in Skyrim in order to add additional effects to them.